材料科学与化学工程学院学术报告——Using Customizable Microparticles to Deliver Medicine to the Cornea and Other Tissues via Ballistic Bombardment
报告摘要：In the Julia Kornfield Laboratory, we are developing a new strategy for drug delivery – we prepare 1- 100 µm microparticles composed of medicine and accelerate them into biological surfaces. By controlling the kinetic energy and material properties of ballistic particles, we can access hard-to-reach layers of tissue in a fast, highly-reproducible manner. This project is motivated by, but not limited to, the desire to use ballistic particles to treat pathologies of the eye. To embed particles in biological tissues, we have designed a continuous device that delivers beams of microparticles moving at high velocity. In this device, particles are aerodynamically focused into a thin beam (< 200 µm) and then accelerated through a capillary until they reach the target tissue. Our ability to make particles with custom density and to focus their motion onto a small target will enable access to deep tissue layers. This technology could become a potential alternative to intravitreal injections and can be used on other tissues to enable fast drug uptake limited by passive diffusion.