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“海洋科学前沿与实践论坛”系列报告之155-156讲

发布日期:2017-06-13 作者:本站编辑

时间:2017614日周三上午900

地点:海洋学院12号楼208会议室

 

报告题目1Scientific Writing for American Chemical Society (ACS) Journals

报告人:Dr. Dale Nagle, Professor

工作单位:美国密西西比大学药学院

专家简介:

Dr. Nagle earned his Ph.D. in Pharmacy in 1994 with William H. Gerwick at the Oregon State University College of Pharmacy. His graduate research detailed the chemistry and biosynthesis of marine oxylipins and cyanobacterial antitumor agents. He conducted postdoctoral research with Valerie J. Paul at the University of Guam Marine Laboratory and with Steven L. McKnight in the Department of Biochemistry at the University of TexasSouthwestern Medical Center at Dallas. He joined the University of Mississippi Department of Pharmacognosy in 1997. In 2009, he was appointed Full Professor of Pharmacognosy in the UM Department of BioMolecular Sciences. He also holds a visiting International professorship in the Institute of Interdisciplinary Integrative Biomedical Research at the Shanghai University of Traditional Chinese Medicine.

 

Dr. Nagle has co-authored nearly 90 peer-reviewed publications, including eight book chapters. His book chapter on “Mechanism-Based Screening for Cancer Therapeutics” in the Handbook of Marine Natural Products has been integrated into a number of graduate programs. He has made dozens of invited professional presentations and delivered eight plenary lectures at major international scientific conferences in Italy, China, Korea, Poland, England, Norway, and the US.

报告题目2Natural Product Research on Genus Symploca Cyanobacteria for New Therapeutic Agents

报告人:Dr. C. Benjamin Naman

工作单位:美国加州大学圣地亚哥分校

Scripps海洋研究所

专家简介:

Dr. Naman received his Ph.D. in Pharmaceutical Sciences from Ohio State University. He trained in medicinal chemistry and pharmacognosy under the guidance of Professor A. Douglas Kinghorn. Dr. Naman conducted postdoctoral research in marine cyanobacteria devised to identify and develop new anticancer agents for drug discovery with Professor William H. Gerwick at the University of California, San Diego.

 

For millennia, in the case of traditional medicines, and centuries for current Western medicine, natural products have played an important role in clinical pharmacy. With the increased development and availability of new chemical techniques and analytical instrumentation, one great challenge for many years was the linking of natural product chemistry to pharmacology. This was somewhat alleviated by the implementation of bioassay-guided isolation methods. In recent past, however, a new challenge has emerged: high rates of the re-discovery of known molecules. The identification of already reported compounds can truly benefit a research program in many ways, but it does negatively impact pharmaceutical research due to the strong desire for easier intellectual property (IP) protection of inventions. There is thus a great need for new methods to improve the rate of novel bioactive natural product isolation and discovery. In this presentation, it will be shown how the use of one such method, LC-MS/MS based molecular networking, has aided in the efficient discovery of new bioactive (cytotoxic or ion channel modulatory) natural products from an already pharmaceutically important genus of Marine Cyanobacteria, called Symploca.