报告人：Dr. Dale Nagle, Professor
Dr. Nagle earned his Ph.D. in Pharmacy in 1994 with William H. Gerwick at the Oregon State University College of Pharmacy. His graduate research detailed the chemistry and biosynthesis of marine oxylipins and cyanobacterial antitumor agents. He conducted postdoctoral research with Valerie J. Paul at the University of Guam Marine Laboratory and with Steven L. McKnight in the Department of Biochemistry at the
Dr. Nagle has co-authored nearly 90 peer-reviewed publications, including eight book chapters. His book chapter on “Mechanism-Based Screening for Cancer Therapeutics” in the Handbook of Marine Natural Products has been integrated into a number of graduate programs. He has made dozens of invited professional presentations and delivered eight plenary lectures at major international scientific conferences in
报告人：Dr. C. Benjamin Naman
Dr. Naman received his Ph.D. in Pharmaceutical Sciences from
For millennia, in the case of traditional medicines, and centuries for current Western medicine, natural products have played an important role in clinical pharmacy. With the increased development and availability of new chemical techniques and analytical instrumentation, one great challenge for many years was the linking of natural product chemistry to pharmacology. This was somewhat alleviated by the implementation of bioassay-guided isolation methods. In recent past, however, a new challenge has emerged: high rates of the re-discovery of known molecules. The identification of already reported compounds can truly benefit a research program in many ways, but it does negatively impact pharmaceutical research due to the strong desire for easier intellectual property (IP) protection of inventions. There is thus a great need for new methods to improve the rate of novel bioactive natural product isolation and discovery. In this presentation, it will be shown how the use of one such method, LC-MS/MS based molecular networking, has aided in the efficient discovery of new bioactive (cytotoxic or ion channel modulatory) natural products from an already pharmaceutically important genus of Marine Cyanobacteria, called Symploca.